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KMID : 1101420220540020149
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Korean Journal of Clinical Laboratory Science
2022 Volume.54 No. 2 p.149 ~ p.156
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The Relationship between Lipid Accumulation Product, Insulin Resistance and Obesity in Korean Adults
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Yoon Hyun
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Abstract
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Lipid accumulation product (LAP) is a new index reflecting central lipid accumulation and is known to be a strong independent indicator for identifying the risk of cardiovascular disease (CVD) or diabetes mellitus (DM). This study was conducted to assess the relationship between the homeostasis model assessment of insulin resistance (HOMA-IR) and LAP according to the presence or absence of obesity in Korean adults. The study was carried out using data from the 2019 Korean National Health and Nutrition Examination Survey (KNHANES) and included 6,090 adults aged 20 years or older. There were several key findings. First, after adjusting for related variables, the mean of the HOMA-IR levels (M±SE, 95% confidence interval) was positively associated with the quartiles of LAP in the overall population (P＜0.001), non-obese (P＜0.001) or obese groups (P＜0.001). Second, in all the groups (overall population, non-obese and obese groups), the mean value of the fasting blood glucose (all, P＜0.001), insulin (all, P＜0.001), and the metabolic syndrome score (all, P＜0.001) increased with the increasing quartiles of LAP. Insulin resistance was thus positively associated with an increase in the LAP in Korean adults with or without obesity.
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KEYWORD
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Insulin resistance, Lipid accumulation product, Metabolic syndrome, Obese
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